The European Commission, in March 2022, announced a target for the production of 35 billion cubic metres of biomethane within the EU by 2030. The EU produces 3 billion cubic metres of biomethane today. So plans to scale up require the mobilisation of sustainable biomass feedstock. In this context, the EU-funded SEMPRE-BIO project will develop novel and cost-effective biomethane production solutions and pathways. Specifically, it will set up three European biomethane innovation ecosystems based in Adinkerke (Belgium), Baix Llobregat (Spain) and Bourges (France), which are representative of the different baseline situations for biomethane production across Europe. The project will design a process by which more innovators and entrepreneurs will be able to launch larger-scale and cheaper production of biomethane faster.