Code
3F018709
Duration
01 October 2009 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Immunology
- Morphological sciences
- Oncology
- Immunology
- Morphological sciences
- Oncology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Immunology
- Morphological sciences
- Oncology
Keywords
gene therapy
non-viral delivery systems
anti-cancer immunity
mRNA vaccination
Project description
We will evaluate non-viral delivery systems for mRNA vaccination against cancer in mouse-models. Therefore, we will first study the biodistribution, the level and the kinetics of the gene expression of mRNA/liposome or mRNA/polymer complexes in mice. Additionally, the immunological response and tumor growth will be evaluated after the delivery of a mRNA vaccine complexed with the most efficient non-viral delivery system.