Project

Host cytoskeleton machinery proteins affecting HIV replication

Duration
01 October 2010 → 30 September 2013
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
cytoskeleton HIV therapeutic intervention AIDS CD4 RNAi monocytes peripheral blood lymphocytes
 
Project description

The Human Immunodeficiency Virus (HIV) takes advantage of the host cell cytoskeleton machinery for infection. The identification of cellular proteins interacting with proteins of HIV during its life cycle is important for the identification of new targets for therapeutic intervention. To achieve this, genome-wide shRNA screenings will be performed in HIV infected peripheral blood lymphocytes CD4+ and monocytes.