Project

The development of a flow sheet model for a full continuous pharmaceutical from-powder-to-tablet manufacturing line to gather process knowledge and the development of control strategies

Duration
01 October 2014 → 30 September 2020
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Applied mathematics in specific fields
    • Computer architecture and networks
    • Distributed computing
    • Information sciences
    • Information systems
    • Programming languages
    • Scientific computing
    • Theoretical computer science
    • Visual computing
    • Other information and computing sciences
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
Flow sheet model PBM production of tablets Farmaceutical processes continuous production mechanistic modelling CFD
 
Project description

Mechanistic models of pharmaceutical processes are required to predict and control the continuous production of tablets based on real-time measurements and adjustment of significant process variables. The development of these models will adopt a step-wise approach. In this project the focus will be the modelling of a full continuous from-powder-to-tablet manufacturing line