Recently, we identified ETV6 as a gene, recurrently implicated in a specific leukemia subclass (ETP-T-ALL). Although ETV6 is a well-known leukemia gene, the ways in which it contributes to leukemia remain unexplored. In this project, we will study how ETV6 functions in normal T-cell development and T-ALL. This project will lead to groundbreaking insights in ETP-T-ALL development and progression.