Project

Development of in vitro and in vivo models for efficacy and safety testing of mycotoxin detoxifying agents

Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Animal biology
  • Agricultural and food sciences
    • Agricultural animal production
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
intestinal cell cultures toxicokinetics mycotoxins LC-MS/MS mycotoxin detoxifying agents
 
Project description

The in vitro models concern cytotoxicity and permeability studies using intestinal cell cultures and intestinal explants. The in vivo modelling is mainly based on toxicokinetical studies in pigs and poultry. Both efficacy, mycotoxin binding or biotransforming ability, and safety, interaction with drug absorption, is of interest.