Epimerases as new tools for the production of rare sugars: a powerful integration of enzyme engineering and systems biocatalysis

01 October 2016 → 31 August 2020
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
enzyme engineering Epimerase sugars
Project description

In this project we aim to develop new pathways for the biocatalytic synthesis of rare sugars and derivatives. To that end, various enzymes will be optimized by protein engineering and then combined in a one-pot reaction vessel. The process starts from sucrose as abundant and renewable resource and allows obtaining the target products with high yields and minimal costs.