The four-top quark process eludes discovery since the start of the LHC. Its spectacular final states are sensitive to many phenomena beyond the standard model (BSM) but subject to large backgrounds. With novel analysis techniques optimized at each step, the LHC Run 3 data presents an opportunity to close this gap and surpass the discovery threshold. Because there is little known about subtle theoretical effects in kinematic spectra at next-to-leading order, a tandem with developments in effective field theory (SM-EFT) is needed. Building on the expertise of the three principal investigators Dr. Robert Schöfbeck (Austrian Academy of Sciences), Prof. Dr. Didar Dobur (Ghent University, Belgium), and Prof. Dr. Francesco Riva (University of Geneva, Switzerland), we devise a comprehensive experimental and theoretical analysis of the four-top production at the LHC. On the experimental side, we propose to analyse all leptonic four-top final states combined in a consistent treatment of backgrounds and uncertainties. Novel machine learning techniques play a central role in tackling the experimental challenges. On the theoretical side, SM-EFT provides a versatile BSM framework for turning the experimental measurement regions into sensitive BSM searching tools. The close interlock of theoretical and experimental developments is unique in the field. An SM-EFT interpretation with the complete set of top quark operators will be performed for the first time