Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics

01 February 2015 → 31 January 2019
European funding: framework programme, Regional and community funding: Special Research Fund
Research disciplines
  • Engineering and technology
    • Other (bio)chemical engineering not elsewhere classified
heart failure
Other information
Project description

Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, microoptics, micro-optical laser bench, optical package•ntegrate the subsystems and build a multi-array laser interferometer system, develop a process flow scalable to high volumes for all sub-systems and their integration steps•nvestigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events, validate the system in a clinical settingPhotonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.

Role of Ghent University
Ghent University is involved at two levels: Design of silicon photonics chips (in collaboration with imec) – prof. Roel Baets and Dr. Danaë Delbeke Biomechanical in-vitro and in-silico assessment of LDV for cardiovascular screening and early diagnosis – prof. Patrick Segers