Patients with kidney cancer that has spread, are often treated with the tyrosine kinase inhibitor substance (TKR). This substance acts targeted by the growth of the tumor cells and the blood vessels to the tumor to slow down. This treatment often works only temporarily, and some patients do not respond to. The aim of the study is to investigate whether the effect of TKR is stronger in combination with a highly-oriented (= stereotactic) radiation therapy against metastases. The advantage of this targeted radiotherapy is that the surrounding, healthy body tissues are damaged less. Moreover, it was shown that this form of radiation therapy can boost the immune system so that the tumor can attack efficiently. This technique combined with TKR, hopes the team of Professor Ost more people will respond favorably to treatment. The study will first consider whether this combined treatment is not toxic to the patient, and secondly assess the effect on metastasis.