The ability to self-repair damaged tissue is one of the key features that define living organisms. In humans and animals, damaged tissue can be replenished through the activity of stem cells. These basic, undifferentiated cells will divide to produce new cells that replace the damaged tissue cells. Plants are characterized by a similar system, but their regenerative properties are generally much greater. While this asset has been widely used in grafting and plant tissue culture techniques, the mechanisms by which plant cells are triggered to form new cells after injury remain largely elusive. Recently, we uncovered a novel protein complex controlling tissue repair in plants. One dead plant cell is sufficient to activate the protein complex in its neighbouring cells. As a result, these cells are triggered to divide in such a way that the newly produced cells substitute the dead ones. Preliminary data indicate that, next to the identified protein complex, related transcription factor complexes exist with a similar role in tissue recovery. Within this project, we aim to categorize these different protein complexes in a systematic manner, localize their activity, and identify their substrates. Our results might help to achieve a full understanding of plant regeneration. This knowledge might be applicable to crop species, thereby increasing cultivation efficiency and reducing grafting failure rates.