Research Explorer

Project

The role of dopamine D4 receptor ubiquitination and functional differences between the polymorphic receptor variants
Code
3F017311
Duration
01 October 2011 → 30 September 2015
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
dopamine D4 receptor ubiquitination KLHL12
 
Project description

The ubiquitination of the dopamine D4 receptor (DRD4), a G protein-coupled receptor (GPCR), is enhanced upon its interaction with a BTB-Kelch protein, KLHL12. We have shown that the KLHL12-induced DRD4 polyubiquitination does not play a key role in receptor degradation. In the current research we are investigating the role of ubiquitination in receptor signaling.