Project

The role of HIV Nef in viral fitness and pathogenicity

Code
31502808
Duration
01 January 2008 → 31 December 2010
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
dendritic cells nef HIV
 
Project description

Nef is the viral protein crucial for immune evasion in HIV infection and AIDS. We measure its contribution to viral replication and transmission fitness. We want to identify relevant domains in the protein by using primary isolates and mutants. Our goal is to unravel the mechanism of Nef function on the molecular level.