Neuromuscular disorders include the heterogeneous groups of inflammatory myopathies (IM) and muscular dystrophies (MD). Research strategies are to map the regulatory pathways of immunoregulation and cell survival in well-characterized disease subtypes and in animal models to provide mechanistic insight of the different disease mechanisms. For this purpose, state-of-the-art myopathologic, RNAomic, proteomic and functional protocols will be used. Novel circulating factors with key pathologic roles will be proposed as diagnostic biomarkers and will be developed into screeners for disease prognosis and to assess therapeutic responses. Deciphering the regulatory complexity will offer data to explain and/or predict therapy refractory disease, and could lead to the identification of novel therapeutic targets. In particular, the proposition of osmoprotection and corrected autophagy as a therapeutic strategy will be explored in zebrafish disease models.