Synthesis and study of the reactivity of functionalized small-membered azaheterocyclic amino acid derivatives.

01 February 2009 → 31 October 2012
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Other chemical sciences
  • Agricultural and food sciences
    • Agricultural plant production
azetidines nonproteinogenic amino acids aziridines
Project description

The synthesis of constrained aziridine-2-carboxylic acid derivatives and azetidine-3-carboxylic acid derivatives is of great importance in agricultural and medicinal chemistry. This research concerns the development of syntheses of new functionalized derivatives of aziridine-2-carboxylic acid and azetidine-3-carboxylic acid. The study of their further transformations and ring opening reactions towards potentially physiologically active amino acid derivatives, and their application in the synthesis of peptides are also performed in this research.