Cryostat to generate cryo sections for the histology core of the Faculty of Veterinary Medicine

15 December 2022 → 14 December 2024
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Small molecules
  • Agricultural and food sciences
    • Veterinary anatomy, morphology and (clinical) pathology
    • Veterinary embryology
    • Veterinary oncology
    • Veterinary pharmacology and toxicology
cryosections spatial omics transcriptomics genomics laser microdissection proteomics mass spectrometry histology small molecules
Project description

The consortium aims to acquire a novel cryostat to replace the existing, but partly broken device at the histology facility of the laboratory of Veterinary Morphology. With the new cryostat, the histology laboratory will remain a state of the art facility, able to ensure its current research service as histology facility at the faculty of Veterinary Medicine and beyond. Moreover, the cryostat will also ensure the continuation of our focus on developing spatial-omics methods to analyze RNA, DNA, proteins and small molecules in histological sections. A state of the art cryostat, which allows contamination free sectioning, is required for laser capture microdissection and for using ultrasensitive mass spectrometry in combination with imaging. These methods are available at the consortium partners and are embedded in existing core facilities, i.e. the center for advanced light microscopy and the MSsmall expertise center, ensuring the university wide usage of this equipment.