Project

Further exploration of the role of indoleamine 2,3-dioxygenase (IDO) as a possible mechanism of immune-escape in melanoma.

Duration
01 October 2012 → 31 August 2015
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • General biology
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
melanoma immunotherapy IDO
 
Project description

Melanoma is a tumor with efficient immune-escape mechanisms, evading the host response. Our research group has demonstrated a worse prognosis in patients with IDO expression (an immunosuppressive enzyme) in the sentinel lymph node. We want to further investigate the driving mechanisms and immunological changes in IDO+ patients, and test an IDO-inhibitor as a novel immunotherapy in a mouse melanoma model.