Code
01D39009
Duration
01 October 2009 → 01 March 2011
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Organic chemistry
-
Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
Keywords
NKT cells
KRN 7000
synthesis
Project description
Synthesis of sugar- modified alpha-galactosylceramide (KRN 7000) analogues that potentially induce a Th1- polarised cytokine response mediated by NKT cells. The proposed modifications intent to establish an improved binding affinity with the CD1d protein, which should result in a bias towards a TH1 respons.