Process intensification (PI) plays an essential role in the new paradigm of chemical engineering, which is characterized by any technology that leads to a substantially smaller, cleaner, and more energy-efficient process with multiscale cognition. However, the development of process intensification technologies, such as reactor development, is a very challenging task because of the inherent complexity in momentum/heat/mass transfer, mixing, sourcing and/or storing of reactants, products, or catalysts, transport processing, etc. The use of multi-scale computation and modelling has led to breakthroughs in the design and optimization of chemical equipment and processes. With my research group I intend to build a research framework to effectively and efficiently develop process intensification technologies by coupling (1) lab-scale fundamental experiments, (2) computational fluid dynamics (CFD) simulations & optimization and (3) process simulations & assessment, allowing low-cost process innovation from reactor-scale, bench-scale to pilot-scale.