Research Explorer

Project

Alphaherpesviruses and the innate antiviral defence in the respiratory and genital tract: a fight for supremacy
Code
01GB1317
Duration
01 January 2017 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Cellular interactions and extracellular matrix
  • Medical and health sciences
    • Innate immunity
    • Virology
Keywords
innate immunity herpes simplex virus type 1 & 2 animal alphaherpesviruses (pseudorabies virus bovine herpesvirus 1) pseudorabies virus respiratory tract
 
Project description
 

Alphaherpesvirus infections cause respiratory and genital problems in humans and animals. In the present project proposal, it will be examined how alphaherpesviruses cross different barriers of the respiratory and genital mucosa (mucus, defensins, basement membrane) and how they escape local innate immunity (interferon, ILC/NK cells). The research results will contribute to the development of new/better drugs and vaccines.