Research Explorer

Project

Role of ABCC6, a transmembrane transporter in the liver, in connective tissue homeostasis, using Pseudoxanthoma Elasticum as a model
Code
3G024111
Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Dermatology
    • Molecular and cell biology
    • Orthopaedics
    • Dermatology
    • Orthopaedics
    • Dermatology
    • Molecular and cell biology
    • Orthopaedics
Keywords
ABCC6-transmembrane transporter vitamin k pseudoxanthoma elasticum
 
Project description

This project aims to elucidate the identity of the substrate of the ABCC6 transporter which is disturbed in Pseudoxanthoma Elasticum (PXE), an autosomal recessive genodermatosis. It also wants to explore the relationship to the deficient mineralization of connective tissues in this disorder and to investigate the role of vitamin K in the aberrant calcification process.