Code
01D38811
Duration
01 October 2011 → 30 September 2015
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Social sciences
- Biological and physiological psychology
- Cognitive science and intelligent systems
- Developmental psychology and ageing
-
Medical and health sciences
- Neurosciences
- Physiology
- Neurosciences
- Physiology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Neurosciences
- Physiology
Keywords
animal model
cell penetrating peptides
blood-brain barrier
Project description
The rate, extent and region-selectivity of CPP brain penetration will be quantitatively determined. The most representive CPPs will be selected and coupled to BBB-homing peptides. Then a LC-MS method will be developed and evaluated to quantify CPPs. Finally different techniques will be applied to quantify the selective brain interaction and uptake in cell and mouse models.