Project

The Seahorse XFe96 analyzer to decipher cellular bioenergetics and mitochondrial dysfunction after exposure to food and environmental stressors.

Code

01B12020

Duration

01 December 2020 → 30 November 2022

Funding

Regional and community funding: Special Research Fund

Promotor

Andreja Rajkovic

Research disciplines

Medical and health sciences
- Dietetics and molecular nutrition
- Nutritional physiology
- In vitro testing
- Toxinology
- Bacteriology

Keywords

Food environment health sugars toxins contaminants bioactive molecules mitochondria bioenergetics NAFLD NASH

Project description

Here, we request an on-line probe-based extracellular flux analyzer for the studies of cellular bioenergetics. Bioenergetics comprises respiration and enzymatic/molecular systems for ATP generation. Disturbances induced by diet, or food and environmental contaminants, may lead to cellular dysfunction, which is on the basis of chronic diseases (NAFLD, metabolic syndrome, diabetes, cancer,…), and can be in-depth investigated using Seahorse XFe96.