Project

Identification of novel druggable targets through integrated genomic profiling of high risk pediatric solid tumors

Code
bof/baf/4y/2024/01/774
Duration
01 January 2024 → 31 December 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Genetics
    • Cancer biology
    • Cancer therapy
Keywords
genomic profiling Pediatric cancer precision medicine
 
Project description

The cure rate for most pediatric cancer types still remains low. Finding novel targeted therapies is therefore an urgent medical need. Children with cancer are often still treated by a ‘one-fits-all’ approach, given the limited available entry points for targeted therapy. Current advances in the molecular dissection of pediatric cancers using multiple layers of information, yield fundamental insights into novel putative targets and strategies for precision oncology. Therefore, building a next-generation precision oncology platform for childhood cancer will require a dedicated multidisciplinary and integrative scientific approach in which state-of-the-art technologies serve as driving force to untangle the genetically rewired networks and fuel contemporary pre-clinical target evaluation. Through my combined appointment as a lab supervisor in the diagnostic work-up of pediatric cancer samples and researcher in pediatric cancer, access to patient samples and technologies will be secured.