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Medical and health sciences
- Genetics
- Cancer biology
- Cancer therapy
The cure rate for most pediatric cancer types still remains low. Finding novel targeted therapies is therefore an urgent medical need. Children with cancer are often still treated by a ‘one-fits-all’ approach, given the limited available entry points for targeted therapy. Current advances in the molecular dissection of pediatric cancers using multiple layers of information, yield fundamental insights into novel putative targets and strategies for precision oncology. Therefore, building a next-generation precision oncology platform for childhood cancer will require a dedicated multidisciplinary and integrative scientific approach in which state-of-the-art technologies serve as driving force to untangle the genetically rewired networks and fuel contemporary pre-clinical target evaluation. Through my combined appointment as a lab supervisor in the diagnostic work-up of pediatric cancer samples and researcher in pediatric cancer, access to patient samples and technologies will be secured.