This project aims to purchase an ultra-high performance liquid-chromatography tandem mass spectrometer, which will be used as a shared platform and ‘workhorse’ for ultra-sensitive analysis of small organic molecules. It concerns essential basic equipment for different research lines within the MSsmall Expertise Centre, more specifically the targeted quantification of disease biomarkers, drugs of abuse, food intake and food contaminants, and organic micropollutants in environmental research.