Project

Structural and functional characterization of class-II classic cadherins end delta-protocadherins

Duration
01 July 2011 → 30 April 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Laboratory medicine
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
phylogenetic analysis protein structure protocadherins molecular interactions gene structure isoforms cadherins knockout mouse
 
Project description

Two poorly characterized cadherin subfamilies will be analyzed in greater depth. For type-II classic cadherins, focus will lie on phylogenetic analyses, gene structure and gene expression analyses, and a selection of gene knockout mice. For delta-protocadherins, focus will lie on identification of molecular interaction partners, on contribution to protein structure determinations, and on phenotyping of some recently generated knockout mice.