Structural and functional characterization of class-II classic cadherins end delta-protocadherins

01 July 2011 → 30 April 2016
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Laboratory medicine
  • Agricultural and food sciences
    • Veterinary medicine
phylogenetic analysis protein structure protocadherins molecular interactions gene structure isoforms cadherins knockout mouse
Project description

Two poorly characterized cadherin subfamilies will be analyzed in greater depth. For type-II classic cadherins, focus will lie on phylogenetic analyses, gene structure and gene expression analyses, and a selection of gene knockout mice. For delta-protocadherins, focus will lie on identification of molecular interaction partners, on contribution to protein structure determinations, and on phenotyping of some recently generated knockout mice.