Code
3F023915
Duration
01 October 2015 → 30 September 2020
Funding
Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other basic sciences
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other clinical sciences
- Other health sciences
- Nursing
- Other paramedical sciences
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Other translational sciences
- Other medical and health sciences
Keywords
glucocorticoids
TNF
sepsis
Project description
In this project, the exact role of TNF in polymicrobial sepsis will be studied. We hypothesize that
TNF has a double role in sepsis, namely a “good” and a “bad” role and thus that inhibition of TNF
leads to no therapeutic results. We believe that specific inhibition of TNFR1 on the relevant cells, combined with a cell-specific targeting of TNF and GC treatment can form the basis of a new therapy for sepsis.