The emotional connections that exist between people are central to human nature, and several challenges our society is facing, can be brought back to disruptions of this emotional connectedness. However, the current practice in behavioral science is not fully adept to address these challenges, as most research focuses on intra-personal processes, is static in nature, and/or does not take into account the broader social context or culture in which behavior takes place. Therefore, we propose a radically interpersonal, dynamical research agenda to uncover what constitutes (mal)adaptive interpersonal emotional functioning across and between domains of family, work, cultural, and mental life. Our proposal extends and optimizes data collection efforts, pinpoints the relevant types of emotional connectedness across domains, and identifies the contexts that are optimally diagnostic for the prediction of important individual, social, and societal outcomes.