Research Explorer

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Project

Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy

Outputs and Outcomes

Publications

The thymus road to a T cell : migration, selection, and atrophy

Mario Ruiz PérezPeter VandenabeelePeter Tougaard

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury.

Christopher AndersonLaura BoeckaertsPriscilla ChinJavier BurgoaWei XieAmanda GonçalvesGillian BlanckeSam BensonSebastian RogattiMariska S. SimpsonAnna DaveySze Men ChoiSandrien DesmetSummer D. BushmanGeert GoeminnePeter VandenabeeleMahesh S. DesaiLars VereeckeKodi Ravichandran et al.

A1 Journal Article in CELL HOST & MICROBE

RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia

Onay VeliOyku KayaAna Beatriz VarandaXimena HildebrandtPeng XiaoYann EstornesMatea PoggenbergYuan WangManolis PasparakisMathieu BertrandHenning WalczakAlessandro AnnibaldiAlessandra K. CardozoNieves Peltzer et al.

A1 Journal Article in MOLECULAR METABOLISM

Ferroptosis in health and disease

Carsten BerndtHamed AlborziniaVera Skafar AmenScott AytonUladzimir BarayeuAlexander BarteltHülya BayirChristina M BebberKivanc BirsoyJan P BöttcherSimone BrabletzThomas BrabletzAshley R BrownBernhard BrüneGiorgia BulliAlix BruneauQuan ChenGina M DeNicolaTobias P DickAyelén DistéfanoScott J DixonJan B EnglerJulia Esser-von BierenMaria FedorovaJosé Pedro Friedmann AngeliManuel A FrieseDominic C FuhrmannAna J García-SáezKarolina GarbowiczMagdalena GötzWei GuLinda HammerichBehrouz HassanniaXuejun JiangAicha JeridiYun Pyo KangValerian E KaganDavid B KonradStefan KotschiPeng LeiMarlène Le TertreSima LevDeguang LiangAndreas LinkermannCarolin LohrSvenja LorenzTom LueddeAxel MethnerBernhard MichalkeAnna V MiltonJunxia MinEikan MishimaSebastian MüllerHozumi MotohashiMartina U MuckenthalerShohei MurakamiJames A OlzmannGabriela PagnussatZijan PanThales PapagiannakopoulosLohans Pedrera PuentesDerek A PrattBettina PronethLukas RamsauerRaphael RodriguezYoshiro SaitoFelix SchmidtCarina SchmittAlmut SchulzeAnnemarie SchwabAnna SchwantesMariluz SoulaBenedikt SpitzlbergerBrent R StockwellLeonie ThewesOliver Thorn-SesholdShinya ToyokuniWulf TonnusAndreas TrumppPeter VandenabeeleTom Vanden BergheVivek VenkataramaniFelix C E VogelSilvia von KarstedtFudi WangFrank WestermannChantal WientjensChristoph WilhelmMichele WölkKatherine WuXin YangFan YuYilong ZouMarcus Conrad et al.

A1 Journal Article in REDOX BIOLOGY

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

Diego Rojas RiveraSebastián BeltránFrancisco Muñoz-CarvajalPablo Ahumada-MontalvaLorena AbarzúaLaura GomezFernanda HernandezCristian A BergmannLuis LabradorMelissa Calegaro-NassifMathieu BertrandPatricio A ManqueUte Woehlbier et al.

A1 Journal Article in AUTOPHAGY

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia RoelandtAmanda GonçalvesRiet De RyckeKodi RavichandranBart LambrechtTom TaghonGeorges LeclercqPeter VandenabeelePeter Tougaard et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Teodora-Eugenia OlteanJonathan MaelfaitXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH DISCOVERY

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim DeclercqTom Vanden BergheJonathan MaelfaitPeter VandenabeelePeter Tougaard et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi TakahashiSophie JanssensTerkild B. BuusTom TaghonGeorges LeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENCE ADVANCES

Decoding immunogenic cell death from a dendritic cell perspective

Sophie JanssensSofie RennenPatrizia Agostinis

A1 Journal Article in IMMUNOLOGICAL REVIEWS

A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs

Benjamin CappePeter VandenabeeleFranck Riquet

A1 Journal Article in FEBS JOURNAL

Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma

Jelle VerhoevenKathryn A. JacobsFrancesca RizzolloFrancesca LodiYichao HuaJoanna PoźniakAdhithya Narayanan SrinivasanDiede HoubaertGautam ShankarSanket MoreMarco B. SchaafNikolina Dubroja LakicMaarten GanneJochen LamoteJohan Van WeyenberghLouis BoonOliver BechterFrancesca BosisioYasuo UchiyamaMathieu BertrandJean Christophe MarineDiether LambrechtsGabriele BergersMadhur AgrawalPatrizia Agostinis et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis

Benjamin CappeMike VadiEliza SackLudivine WacheulBruno VerstraetenSara DufourJulien FranckWei XieFrancis ImpensAn HendrixDenis L J LafontainePeter VandenabeeleFranck Riquet et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Cell death checkpoints in the TNF pathway

Jon HuygheDario PriemMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Emily Van SanAngela DebruyneGeraldine VeeckmansYulia Y. Y. TyurinaVladimir A. A. TyurinHao ZhengSze Men ChoiKoen AugustynsGeert van LooBernhard MichalkeVivek VenkataramaniShinya ToyokuniHuelya BayirPeter VandenabeeleBehrouz HassanniaTom Vanden Berghe et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of RIPK1 kinase does not affect diabetes development : beta-cells survive RIPK1 activation

Tatiana TakiishiPeng XiaoMarie FranchimontEduardo H. GilglioniErick N. ArrobaEsteban N. GurzovMathieu BertrandAlessandra K. Cardozo

A1 Journal Article in MOLECULAR METABOLISM

From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

Camilla ScarpelliniSophie ValemboisKenneth GoossensMike VadiCaroline LanthierGreta KlejborowskaPieter Van der VekenHans De WinterMathieu BertrandKoen Augustyns

A1 Journal Article in FRONTIERS IN CHEMISTRY

LC3-independent autophagy is vital to prevent TNF cytotoxicity

Dario PriemJon HuygheMathieu Bertrand

A1 Journal Article in AUTOPHAGY

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells

Roberto Fernández-AcostaBehrouz HassanniaJurgen CaroenBartosz WiernickiDaniel Alvarez-AlminaqueBruno VerstraetenJohan Van der EyckenPeter VandenabeeleTom Vanden BergheGilberto L. Pardo-Andreu

A1 Journal Article in CELLS

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom DelangheAllison M. BealBrad GeddesJohn BertinTom Vanden BergheJoyceline De VolderTania MaesPeter VandenabeeleBart M. VanaudenaerdeDieter DeforceSonja SkevinFilip Van NieuwerburghFien VerhammeGuy JoosSobia IdreesHerbert B. SchillerAli Önder YildirimAlen FaizMathieu BertrandGuy BrussellePhilip M. HansbroKen Bracke et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Peter VandenabeeleGeert BultynckSavvas Savvides

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Sam BlanchettYves DondelingerAlessandro BarbaruloMathieu BertrandBenedict Seddon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Spectrally tunable Förster resonance energy transfer-based biosensors using organic dye grafting

Marco Dalla VecchiaAmandine Conte-DabanBenjamin CappeWim VandenbergPeter VandenabeeleFranck RiquetPeter Dedecker

A1 Journal Article in ACS SENSORS

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander BotzkiLars VereeckeGeert van LooWim DeclercqSun HurPeter VandenabeeleJonathan Maelfait et al.

A1 Journal Article in NATURE

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz WiernickiSophia MaschalidiJonathan PinneySandy Adjemian CataniTom Vanden BergheKodi RavichandranPeter Vandenabeele

A1 Journal Article in NATURE COMMUNICATIONS

Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer

Teodora-Eugenia OlteanLien LippensKelly LemeireCaroline De TenderMarnik VuylstekeHannelore DenysKatrien VandecasteelePeter VandenabeeleSandy Adjemian Catani

A1 Journal Article in FRONTIERS IN ONCOLOGY

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertMarnik VuylstekeGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan MaelfaitNozomi TakahashiXavier SaelensPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH & DISEASE

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig LambertsGeert DamsWannes WeytsJelle HuysentruytBehrouz HassanniaIrina IngoldSuhas LeleEvelyne MeyerMaya BergRuth SeurinckYvan SaeysAn VermeulenAlexander L. N. van NuijsMarcus ConradAndreas LinkermannMohan RajapurkarPeter VandenabeeleEric HosteKoen AugustynsTom Vanden Berghe et al.

A1 Journal Article in NATURE COMMUNICATIONS

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian PopperAndreas HiergeistPeter TougaardTom Vanden BergheMarie JoossensGeert BerxNozomi TakahashiAdam WahidaPeter Vandenabeele et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonBenjamin PfeutyCaroline De TenderStephan StremerschKoen RaemdonckKen Op de BeeckWim DeclercqFranck RiquetKevin BraeckmansPeter Vandenabeele et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES