Research Explorer

Project

Eicosanoid and T-cell inflammatory network in chronic rhinosinusitis/ nasal polyposis and aspirin exacerbated disease (AERD).
Code
01P07407
Duration
01 October 2007 → 01 October 2008
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Otorhinolaryngology
    • Immunology
    • Otorhinolaryngology
    • Speech, language and hearing sciences
    • Immunology
    • Otorhinolaryngology
Keywords
eicosanoids T-cells aspirin exacerbated disease
 
Project description

Aspirin exacerbated disease is characterized by a Th2 mediated, eosinophilic inflammation and by imbalance of the eicosanoid pathway. Additionally we suggest that deficiency in T-reg suppression may play an important role in the manifestation of the disease. Based on that we aimed to study the phenotype and the regulation of T-cells/TCR and the influence of eicosanoids on T-cell differentiation/activation in CRS/NP-AERD patients.