The ultimate aim of the current project proposal is to meet the needs of dysphagia populations differing in age and physiology with regard to drug intake by enabling the adoption of high-drug loaded pellets co-administered with swallowing gels offering dosing flexibility, tailored dissolution regimes and high acceptability to those populations.

Therefore, current project aims to 

- identify the critical extrusion-spheronization and formulation variables for high drug-loaded pellets 

- study the impact of co-administration of pellet formulations (comprising APIs varying in solubility) with a swallowing gel.

To achieve these aims, model APIs with different properties, different modified release coatings and different swallowing gels will be studied to establish a correlation between these variables and the resulting drug release profiles.