The Human Brain Project (HBP) is a large, integrated brain initiative. Launched under FP7 and continuing through Horizon 2020, the HBP is building the EBRAINS research infrastructure to strengthen global efforts to explore brain complexity. EBRAINS helps HBP and other researchers provide unprecedented knowledge of brain organisation and function, which will advance understanding of the mechanisms of age-related brain diseases that impose a growing socioeconomic burden. Structural, functional and connectivity data generated by the HBP will paint a more complete and detailed picture of the brain, and support the development of brain-inspired computing and other technologies. Under the EU-funded HBP SGA2 project, HBP continued to strengthen global brain research efforts by extending coordination with other brain initiatives and projects.