Investigate the regulation of ZEB1/2 protein stability using an siRNA library screening 

01 January 2016 → 31 December 2018
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
ZEB pathology
Project description

ZEB proteins are essential transcriptional factors involved in various pathological conditions. Modulation of their up/downstream functions have been proposed to be a good basis for development of new/improved therapies for the treatment of aggressive subtypes of cancer, immunological disorders and/or stimulation of tissue repair. Here, we will identify the molecular mechanisms that regulate the ZEB protein stability via a siRNA library screening. The optimized screening system will be a proof of principle to perform a similar screening to find compounds that either induce stability/degradation of ZEB proteins.