Project

Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes and ABC drug transporters in a porcine animal model

Duration
01 October 2015 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
pigs drugs animal model mycotoxins Metabolisme
 
Project description

Mycotoxins are feed and food contaminants which can modulate the expression of genes encoding for CYP450 enzymes and ABC drug transporters and/or may modulate their activity. The goal of this research proposal is to investigate the effect of mycotoxin intake on the pharmacokinetic behavior of CYP450 and ABC substrate drugs in a pig animal model.