The exponentially growing complexity of large entangled quantum systems is a curse for understanding them but also a blessing as it opens up formidable opportunities for creating novel technologies. The field of quantum sciences explores ways of exploiting quantum effects to create quantum devices that are much more powerful than their classical counterparts. The ensuing second quantum revolution is currently in full motion, and novel quantum devices are being conceived in the context of computation, telecommunication, sensing and cryptography. Major challenges for fundamental physics still remain, several of which will be addressed in this proposal that combines the knowledge and interests of six world-leading Belgian groups working in the field of quantum sciences. The central focus is on creating entanglement – the core fuel that drives all quantum power – in state of the art quantum many-body platforms and in quantum sensors. We will construct novel protocols for preparing, certifying and validating the precious entanglement and implement those ideas in state of the art experiments. As such, we will make Belgium ready for the new era of quantum technologies.