Research Explorer

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Project

Fluorinations with implications: enhancing the potential of biologically and medicinally interesting molecules through targeted fluorine introduction

Outputs and Outcomes

Publications

Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Kristian HollingsworthAntonio Di MaioSarah-Jane RichardsJean-Baptiste VendevilleDavid E. WheatleyClaire E. CouncilTessa KeenanHélène LedruHarriet ChidwickKun HuangFabio ParmeggianiAndrea MarchesiWengang ChaiRyan McBerneyTomasz P. KamińskiMatthew R. BalmforthAlexandra TamasanuJames D. FinniganCarl YoungStuart L. WarrinerMichael E. WebbMartin A. FascioneSabine FlitschM. Carmen GalanTen FeiziMatthew I. GibsonYan LiuW. Bruce TurnbullBruno Linclau et al.

U Journal Article in Nature Communications

<i>De Novo</i> Enantioselective Synthesis of Hexafluorinated <sc>d</sc>-Glucose

Sébastien DepienneClement Q. FontenelleMark E. LightKristof Van HeckeBruno Linclau

U Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Harnessing glycofluoroforms for impedimetric biosensing

Alice R. HewsonHenry O. Lloyd-LaneyTessa KeenanSarah-Jane RichardsMatthew I. GibsonBruno LinclauNathalie SignoretMartin A. FascioneAlison Parkin

U Journal Article in CHEMICAL SCIENCE

Molecular dynamics and NMR reveal the coexistence of H-bond-assisted and through-space <i>J</i><sub>FH</sub> coupling in fluorinated amino alcohols

Cassia ChiariPatrick R. BatistaRenan V. ViesserLeonardo A. SchenbergLucas C. DucatiBruno LinclauClaudio F. Tormena

U Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Quantitative Analysis of 2D EXSY NMR Spectra of Strongly Coupled Spin Systems in Transmembrane Exchange

Dmitry ShishmarevClement Q. FontenelleBruno LinclauIlya KuprovPhilip W. Kuchel

U Journal Article in CHEMBIOCHEM

Quantitative analysis of 2D EXSY NMR spectra of strongly coupled spin systems in transmembrane exchange

Dmitry ShishmarevClement Q. FontenelleBruno LinclauIlya KuprovPhilip W. Kuchel

A1 Journal Article in CHEMBIOCHEM

Lipophilicity modulations by fluorination correlate with membrane partitioning

Zhong WangHannah R. FelsteadRobert I. TroupBruno LinclauPhilip T. F. Williamson

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycosylation of vicinal di- and trifluorinated glucose and galactose donors

Kler HuonnicBruno Linclau

A1 Journal Article in CHEMICAL COMMUNICATIONS

Obtaining pure 1H NMR spectra of individual pyranose and furanose anomers of reducing deoxyfluorinated sugars

Gabija PoskaiteDavid E. WheatleyNeil WellsBruno LinclauDavy Sinnaeve

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library

Tessa KeenanNatasha E. HattonJack PorterJean-Baptiste VendevilleDavid E. WheatleyMattia GhirardelloAlice. J. C. WahartSanaz AhmadipourJulia WaltonM. Carmen GalanBruno LinclauGavin J. MillerMartin A. Fascione et al.

A1 Journal Article in CHEMICAL SCIENCE

Photoinduced formation of cubyl aryl thioethers and synthesis of monocubyl analogue of dapsone

Laly Donnier-ValentinSeydou KassambaJulien LegrosCatherine FressigneDaniela VulugaRichard C. D. BrownBruno LinclauMichael De Paolis

A1 Journal Article in ORGANIC LETTERS

The synthesis and glycoside formation of polyfluorinated carbohydrates

Kler HuonnicBruno Linclau

A1 Journal Article in CHEMICAL REVIEWS

Relating conformational equilibria to conformer‐specific lipophilicities : new opportunities in drug discovery

Bruno LinclauZhong WangBenjamin JeffriesJérôme GratonRodrigo J. CarbajoDavy SinnaeveJean‐Yves Le QuestelJames S. ScottElisabetta Chiarparin

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION