Project

The intracellular network surrounding the HIV Nef protein

Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Hematology
    • Immunology
    • Laboratory medicine
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
transmission HIV nef infection shRNA
 
Project description

Cellular partner proteins of HIV Nef are searched for by functional screenings using shRNA lentiviral libraries and expression profiling. We study, in relation to the interacting partners of Nef and Nef induced genes, the immunological synapse formation, T cell response and HIV transmission in T cell – dendritic cell conjugates, using replication competent HIV reporter viruses.