Code
3G009310
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Systems biology
-
Medical and health sciences
- Hematology
- Immunology
- Laboratory medicine
- Hematology
- Immunology
- Laboratory medicine
- Microbiology
- Hematology
- Immunology
- Laboratory medicine
-
Engineering and technology
- Biomaterials engineering
- Biological system engineering
- Biomaterials engineering
- Biomechanical engineering
- Other (bio)medical engineering
- Environmental engineering and biotechnology
- Industrial biotechnology
- Other biotechnology, bio-engineering and biosystem engineering
Keywords
transmission
HIV
nef
infection
shRNA
Project description
Cellular partner proteins of HIV Nef are searched for by functional screenings using shRNA lentiviral libraries and expression profiling. We study, in relation to the interacting partners of Nef and Nef induced genes, the immunological synapse formation, T cell response and HIV transmission in T cell – dendritic cell conjugates, using replication competent HIV reporter viruses.