Research Explorer

Project

Structure-function study with NMR of and insight into the supramolecular assembly of lipopeptide antibiotics from the viscosin group.
Code
3G090110
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analytical chemistry
    • Organic chemistry
Keywords
NMR spectroscopy self-assembly peptide synthesis lipopeptides
 
Project description
 

The relation between monomer structure, supramolecular assembly and the resulting biological function of self-assembling antimicrobial lipopeptides will be studied. The recently shown potential of diffusion relaxation NMR techniques to gain information about the self-assembly will be employed. Next to this, we wish to synthesize a series of non-natural variants, which will elucidate the principles of the self-assembly.