Code
31519907
Duration
01 January 2007 → 31 December 2009
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Macromolecular and materials chemistry
- Organic chemistry
Keywords
combinatorial chemistry
peptide synthesis
organic synthesis
Project description
The current project aims at the development of a new type of dipodal DNA-binding peptides based on the use of a conformationally anchored organic template for the attachment of two recognition-helices. Therefore combinatorial dipodal peptide libraries will be synthesized and screened for DNA-binding capacity. At a later stage we will try to synthezise combined major/minor groove binding peptide dimers.