Project

Photoactivation of caged compounds and live cell confocal calcium imaging at the subcellular level.

Duration
01 September 2014 → 31 August 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
medical basic sciences
 
Project description

The core research theme of the Physiology group of Prof. Dr. L. Leybaert is to elucidate mechanisms and functions of ICWs as a key signaling process in the function of the brain and the cardiovascular system. Plasma mebrane connexins (Cxs) and the channels formed by these proteins importantly contribute to intercellular Ca2+ signaling. Gap junctions (channels directly connecting the cytoplasm of neighboring cells; further abbreviated as GJs) hereby mediate the transfer of IP3 between the cytoplasm of neighboring cells whereas plasma membrane hemichannels (`half of a gap junction channel'; further referred to as HCs) provide a paracrine release pathway for messenger molecules like ATP. Our work is directed at understanding the role of Cx-mediated communication in several pathophysiological processes including blood-brain barrier disruption, cardiac ischemia and arrhythmias, and bystander cell death.