New functions of the BH4 domain of Bcl-2: a critical regulator of Ca2+-permeable channels.

01 January 2012 → 31 December 2017
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Physiology
    • Physiology
    • Physiology
ryanodine receptor mitochondria endoplasmic reticulum Ca2+ voltage-dependent anion channel 1 Bcl-Xl Bcl-2
Project description

We previously found that the anti-apoptotic protein Bcl-2, but not Bcl-Xl, binds to the central, modulatory domain of the inositol trisphosphate receptor through its BH4-domain, thereby inhibiting endoplasmic reticulum (ER) Ca2+ release and apoptosis. This project will explore novel functions of BH4-Bcl-2 and BH4-Bcl-Xl, focusing on the interactions with the ER ryanodine receptor and the mitochondrial voltage-dependent anion channel 1.