Project

'BacVirISG15' - in the framework of ERA-NET Infect-ERA JTC 2016. The Interferon Stimulated Gene 15 (ISG15) modification system in host pathogen interactions: mechanisms, technology and translational potential.

Duration
01 April 2017 → 31 March 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
Keywords
host-pathogen interactions proteomics ubiquitin-like
 
Project description

Novel therapeutic strategies against microbial infections remain limited. In this interdisciplinary project we will investigate the host ISG15 system, induced to counteract a wide range of viral and bacterial pathogens. It’s function relies on linkage of the ISG15 molecule to cellular and microbial proteins. Species-specific aspects of the system will be analyzed to examine the therapeutic potential in humans.