Project

Dynamic modulation of disease progression in chronic gut and joint inflammation in spondyloarthritides

Duration
01 January 2017 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Orthopaedics
    • Gastro-enterology and hepatology
    • Orthopaedics
    • Gastro-enterology and hepatology
    • Orthopaedics
Keywords
spondyloarthritis biomechanical stress microscopic gut inflammation
 
Project description

In this proposal the relation between gut and joint inflammation in spondyloarthritis is investigated by examininng the underlying cellular and molecular mechanisms of inflammation with focus on mechanical strain and immune regulation. Through miniature ecosystems, i.e. pre-adapted microbial cocktails, we aim to boost immune regulatory mechanisms thereby altering the disease course.