Code
365P4513
Duration
01 January 2013 → 31 December 2016
Funding
Funding by bilateral agreement (private and foundations)
Promotor
Research disciplines
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Natural sciences
- Biochemistry and metabolism
- Systems biology
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Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Keywords
signal transduction
ubiquitination
cancer
Project description
Dysregulation of components of the ubiquitin system has been linked to many diseases including cancer. The present project proposal focuses on the de-ubiquitinases CYLD and A20, which have been established as tumor suppressors, and aims to dissect the precise molecular mechanisms that regulate and mediate their activity.