Improved intracellular delivery of upconversion nanoparticles by laser-induced vapor nanobubbles for multimodal bio-imaging applications

01 March 2016 → 31 August 2019
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Applied mathematics in specific fields
  • Medical and health sciences
    • Medical imaging and therapy
    • Medical imaging and therapy
    • Other paramedical sciences
    • Medical imaging and therapy
  • Engineering and technology
    • Multimedia processing
    • Materials science and engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Medical biotechnology
    • Other (bio)medical engineering
    • Signal processing
intracellular delivery vapor nanobubbles bio-imaging laser-induced
Project description

Vapor nanobubble induced membrane poration will be explored as novel method for efficient delivery of upconversion nanoparticles into the cytosol of living cells. Benefits for in vivo cell tracking will be demonstrated over standard endocytic nanoparticle uptake, including improved labeling uniformity, high-throughput cell labeling, reduced toxicity, improved long term visibility and better signal quantification.