Project

The nuclear balance of ZEB transcription factors – a driver of cellular plasticity for initiation and progression of melanoma.

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
ZEB transcription factors melanoma Cellular plasticity
 
Project description

Melanoma is often considered one of the most deadliest human cancers. Recent data suggest a crucial role of the EMT inducing transcription factors ZEB1 and ZEB2 in melanocyte homeostasis and melanoma initiation and progression. During this project, I will further build on our knowledge on the role of the EMT inducing transcription factors ZEB1 and ZEB2 during melanoma progression.