Project

Genetics and physiology of bimodal protein targeting in yeasts. Studies on the basic mechanisms and possible therapeutic developments.

Code

3G0C1514

Duration

01 January 2014 → 31 December 2019

Funding

Research Foundation - Flanders (FWO)

Promotor

Wim Soetaert

Research disciplines

Engineering and technology
- Biocatalysis and enzyme technology
- Industrial biotechnology diagnostics

Keywords

bimodal targetting Candida albicans erg11 P450

Project description

In this project we aim to understand the genetics and molecular biology of bimodal targeting of proteins in yeast. Whereas this mechanism has been described in mammalian cells, this is the first time that it has been found in yeasts. Bimodal targeting furthermore takes part in the acquisition of drug resistance in pathogenic yeasts, an aspect which is also addressed.