Project

Genetics and physiology of bimodal protein targeting in yeasts. Studies on the basic mechanisms and possible therapeutic developments.

Code
3G0C1514
Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Industrial biotechnology diagnostics
Keywords
bimodal targetting Candida albicans erg11 P450
 
Project description

In this project we aim to understand the genetics and molecular biology of bimodal targeting of proteins in yeast. Whereas this mechanism has been described in mammalian cells, this is the first time that it has been found in yeasts. Bimodal targeting furthermore takes part in the acquisition of drug resistance in pathogenic yeasts, an aspect which is also addressed.