Project

Anti-oxidative and anti-inflammatory effects of the heme oxygenase-1/Biliverdin reductase pathway in the gastrointestinal tract.

Code

3G002109

Duration

01 January 2009 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Romain Lefebvre

Research disciplines

Medical and health sciences
- Gastro-enterology and hepatology
- Gastro-enterology and hepatology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Gastro-enterology and hepatology

Keywords

ROS production sGC heme oxygenase-1 Toll-like receptor 4 biliverdine Map kinases

Project description

The anti-oxidative/anti-inflammatory effects of heme oxygenase 1 (H0-1)/biliverdin reductase are studied in the gastrointestinal tract. In vitro peritoneal macrophages and intestinal epithelial cells and in vivo mice are exposed to oxidative and bacterial stress. The influence of endogenous HO-1 induction or of CO-releasing molecules, biliverdine and bilirubine is studied concentrating on the cellular mechanism involved.