Anti-oxidative and anti-inflammatory effects of the heme oxygenase-1/Biliverdin reductase pathway in the gastrointestinal tract.

01 January 2009 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Gastro-enterology and hepatology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Gastro-enterology and hepatology
ROS production sGC heme oxygenase-1 Toll-like receptor 4 biliverdine Map kinases
Project description

The anti-oxidative/anti-inflammatory effects of heme oxygenase 1 (H0-1)/biliverdin reductase are studied in the gastrointestinal tract. In vitro peritoneal macrophages and intestinal epithelial cells and in vivo mice are exposed to oxidative and bacterial stress. The influence of endogenous HO-1 induction or of CO-releasing molecules, biliverdine and bilirubine is studied concentrating on the cellular mechanism involved.